Recent statistics reveal that the average American is consuming 145 Ibs. of sugar a year. The results of this sugar binge are: hyperinsulinemia, hyperlipidemia, obesity, cardiovascular disease, diabetes, Syndrome X, A.G.E. products, cataracts and various forms of neuropathy. These are the chronic diseases of our times. The frontline organ dealing with this glucose onslaught is the pancreas. The increasing levels of diabetes and dysglycemia problems are indicators that the pancreas is not up to dealing with this level of sweetness.
Gymnema sylvestre, a woody climber from the tropical forests of India, has been shown to repair/revitalize/ regenerate the pancreas. In one study, Streppozotocin was used to induce diabetes in rats. Gymnema treated rats had increased insulin secretion and beta cell number. There was no effect on normal rats. Rabbits induced diabetes with AIIoxan showed the same results. Tests in humans with both Type l and Type II diabetes Gymnema was shown to be effective. Gymnema extract was able to reduce blood glucose, glycated hemoglobin, glycosylated plasma proteins, increased C-peptide levels and conventional diabetic drug therapy. These effects are not noted with standard conventional therapy. All patients developed secondary hypoglycemic symptoms and had to have their drug dosages reduced after several weeks.
When tested on healthy individuals, Gymnema does not produce any acute reduction in fasting blood glucose levels. This research is starting to overturn the conventional concept that the pancreatic beta cell in juvenile, maturity-onset and experimentally induced diabetes is irreversible Gymnema extract has the ability to normalize blood glucose function by repairing/revitalizing and regenerating the beta cells of the pancreas.
Gymnema in traditional Indian medicine is known as a stomachic, diuretic, and diabetic controller. In Sanskril it's known as Meshashringi and in Hindi as Gurmar. Both names refer to it's ability to destroy sugar. Gymnema has the interesting property of being able to stop sweet taste. This property was investigated in the early 1900's and a crude fraction known as "gymnemic acid" was isolated. This fraction not only stopped sweet taste but also stopped glycouria.
Modern research has isolated a polypeptide, gurmarin, that is responsible for stopping the sweet taste. Several trilerpenpoid saponins have been isolated that have the blood glucose regulating effect.
Vanadyl sulfate, a salt of the mineral vanadium (vanadium oxysulfate), has demonstrated insulin-like effects on glucose metabolism in both animal and human trials (2,3) Clinical trials have shown a significant decrease in insulin requirements by patients with insulin-dependent diabetes mellitus after vanadyl sulfate therapy and a significant decrease in cholesterol levels in both insulin-dependent and non-insulin-dependent diabetics. There was an increase in basal mitogen-activated protein and S6 kinase activities in mononuclear cells from both groups that mimicked the effect of insulin stimulation in controls.(3)
Vanadyl sulfate given to diabetic rats stimulates glucose uptake and metabolism leading to glucose normalization. Rats with Streptozotocin-induced diabetes were given vanadyl sulfate for three weeks. Although insulin levels were still depressed, glucose tolerance was normalized. Vanadyl Sulfate has also been shown to lower high blood pressure in the same rats, as a result of the reduction in excess insulin. Vanadyl Sulfate is likely to be beneficial for diabetes mellitus. It partially restored insulin production in diabetic rats' pancreas tissue. Three weeks of Vanadyl Sulfate treatment, followed by 13 weeks without it, still protected the size and insulin content of pancreas islets. It also maintained glucose tolerance regardless of insulin levels. In another study on diabetic rats, Vanadyl Sulfate maintained the normal levels of glucose, lipids, creatinine, and thyroid hormone. It also corrected abnormalities in heart function and in glycerol output from adipose tissue.
Muscle cells show increased intake of glucose, amino acids, & insulin. Muscles increase tissue formation and retention. Less protein from muscles is available for fuel, so the body turns to fat for fuel. As the metabolic rate increases, the muscles' sensitivity to Vanadyl appears to increase. Glycogen production is increased in muscle and liver cells. The result: less fat, more muscle, and more endurance. Vanadyl Sulfate is beneficial for diabetes mellitus. It partially restored insulin production, protected the size and insulin content of pancreas islets, maintained glucose tolerance regardless of insulin levels, maintained the normal levels of glucose, lipids, creatinine, and thyroid hormone, corrected heart function, and glycerol output from adipose tissue.
Research in recent years has been published showing that chromium in its nontoxic, triva-lent state bound in an organic complex with nicotinic acid as Glucose Tolerance Factor (GTF) improves insulin function in vitro and in viva. Most chromium used as a GTF supplement comes from Brewer's yeast. Chromium in Brewer's yeast is in the polynicotinate form. Chromium polynicotinate is up to 300% more bio-available than chromium picolinate. Chromium doesn't stimulate the increase of insulin, but rather acts in potentiating the action of the hormone. Human trials have shown that Chromium works in the following ways: reduces fasting glycemia, mean blood glucose and glycated hemoglobin. It lowers cholesterol and triglycerides but less than the other indices.
Newer research points to chromium as being able to sensitize tissues to insulin. This action would be beneficial in insulin resistance and Syndrome X problems.
Chromium not only acts in glucose related problems, but is also involved in body composition and fat distribution. In double blind studies, just the addition of chromium supplementation with no other dietary changes altered the body fat composition to increase nonfat body mass.
One factor affecting chromium stores in the body is the amount of sugar that an individual consumes. Once chromium has acted as a cofactor in insulin response it is excreted in the urine. With the high sugar diet of today, the turnover rate of chromium is quite high. In patients with the highest risk for developing frank diabetes, they need chromium the most. The highest tissue stores of chromium occurs in newborns. As the result of diet and sugar stress, chromium is depleted from the body as we age. Studies have shown that diabetics have lower plasma chromium levels than non diabetics.
Niacin-bound chromium is more bio-available than chromium picolinate. A recent animal study at the University of California found that Chromium Polynicotinate was absorbed and retained up to 311% better than chromium picolinate and 672% better than chromium chloride.
Vitamin B3, also called Niacin, Niacinamide, or Nicotinic Acid, is an essential nutrient required by all humans for the proper metabolism of carbohydrates, fats, and proteins, as well as for the production of hydrochloric acid for digestion. B3 also supports proper blood circulation, healthy skin, and aids in the functioning of the central nervous system. Because of its role in supporting the higher functions of the brain and cognition, vitamin B3 also plays an important role in the treatment of schizophrenia and other mental illnesses. Lastly, adequate levels of B3 are vital for the proper synthesis of insulin, and the sex hormones such as estrogen, testosterone, and progesterone.
Chromium taken with Niacin has been found to be a synergistic combination, that increases glucose utilization beyond that when taking Niacin or Chromium alone.
SERVING SIZE: Approx. 5 Drops (0.19ml)
SERVINGS PER CONTAINER: Approx. 160
AMOUNT PER SERVING:
Niacin 1.80 mg
Chromium Polynicotinate 2.4 mcg
Gymnema Sylvestre 5.56 mg
Methylsulfonylmethane (MSM) 0.60 mg
Boron Chelate 25 mcg
Vanadyl Sulfate 1.40 mcg
Purifed Water, Glycerine, Stevia, Natural Flavors.
Take 5 drops in the mouth three to five times per day, or as directed by a health care professional. Shake well before using. For best results, hold in the mouth for two minutes, swish in mouth before swallowing.