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Ocular Formula 90 cap

Ocular Formula 90 cap

Code: 827026
Price: USD $25.57
Shipping Weight 0.50 pounds
Category: Professional
Manufacturer: Rx Vitamins
Mfr Code: 1700
NDC: 708429140603

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Product Description
Designed to Help Maintain Optimal Vision

The Ocular Formula is a comprehensive blend of photo-protective nutrients that provide an effective defense against environmental assults.

Numerous clinical trials and articles in the scientific literature have confirmed the safety and efficacy of lutein, zeaxanthin, bilberry and citrus flavonoids.

These nutrients provide structural support and protection for the retina and cornea, and the ocular connective tissue.

Per two capsules:
Vitamin C 200 mg
Citrus bioflavonoid complex 100 mg ( active flavonols, flavonones, flavones, and naringen 40 %)
Vitamin E ( d-alpha tocopherol succinate with naturally occuring beta, gamma, and delta tocopherols) 100 i.u
Zinc (zinc L-monomethionine) 30 mg
Glutathione ( pharmaceutical grade amino acid) 10 mg
Beta carotene(dunaliella salina) 9 mg
Vitamin A (retinol) 5000 i.u
Selenium (selenomethionine) 50 mcg
Lutein 6 mg
Zeaxanthin 260 mcg
Bilberry (standerdized 25% anthocyanosides) 100 mg
Grape seed (standerdized 95% proanthocyanidins) 10 mg
COQ10 5 mg, Copper(glycinate) 3 mg.

Suggested Use:
Take one capsule two times daily with meals

Macular Degeneration, cataracts and glaucoma are the most common diseases of the eye. Macular degeneration is the physical disturbance of the center of the retina called the macula. A cataract is a cloudy or opaque area in the normally transparent lens of the eye. Glaucoma is a condition when the intraocular pressure is too high for the health of the eye and may cause damage to the optic nerve. All of these problems may eventually lead to blindness. The lens of the eye and surrounding fluid is extremely susceptible to damage from sunlight, oxidative stress, and exposure to various chemicals and pollutants (1). With the aging population and continued depletion of the ozone layer a significant amount of research is now focusing on protecting the eyes from these dangers. Most of this research is in the area of lipid peroxidation and antioxidant nutrients. The eye, and specifically the outer retina, is rich in polyunsaturated fatty acids (PUFA) and susceptible to lipid peroxidation (2). Japanese investigators found that deficiencies of antioxidants can deplete our protective capabilities against peroxidation thus substantially increasing the occurrence of lipid peroxidation (3).

Vitamin C (ascorbic acid) is found in high concentrations in various portions of the eye (4). Vitamin C is a powerful water-soluble antioxidant with numerous epidemiologic studies demonstrating that increased vitamin C concentrations are associated with reduced risk of cataracts (5). Cataract formation is believed to result from oxidative damage due in part to deficiencies of lens vitamin C composition (6). Glaucoma, another potential blinding disease, is also thought to be associated with lipid peroxidation. Researchers believe increased intraocular pressure that causes glaucoma is due to decreased concentration of ascorbic acid in the fluid surrounding the eye (7). Supplementing with vitamin C has proven to be a very effective method to increase both serum and lens ascorbate levels, therefore protecting the eye from oxidative damage (8).

Citrus flavonoids are poly phenolic compounds that exhibit powerful antioxidant properties (9&10). Oxidative stress, mediated by reactive oxygen species (ROS), has been implicated in many degenerative diseases including disorders of the eye. Flavonoids are known to be effective in scavenging free radicals by interfering with ROS and protecting cells from oxidative damage (11). Flavonoids can also help prevent diabetic cataracts by inhibiting the enzyme aldose reductase (12). Aldose reductase is an intracellular enzyme that converts glucose to sorbitol. In diabetic patients excessive sorbitol accumulation in the eye has been implicated in the pathogenesis of cataracts and retinopathy (13).

Vitamin E is undoubtedly the most widely researched antioxidant nutrient and well accepted for its ability to protect cell membranes from peroxidation damage due to free radical reactions (14). Natural source vitamin E (d-alpha tocopherol) has been shown to have higher biological activity and greater tissue uptake than synthetic vitamin E {dl-alpha tocopherol} (14). Research has shown that natural vitamin E can protect against cataract formation by preventing oxidative damage in the lens (15). The researchers noted that individuals with high plasma levels of vitamin E have a reduced risk of cataract formation (15) and low plasma vitamin E can increase risk of cataracts (16). Vitamin E also has the ability to protect cells from light induced damage that contributes to cataracts and may help prevent other diseases of the eye such as retinal photodeterioration (17). The evidence clearly shows that oxidative stress plays a role in the pathogenesis of cataracts and that vitamin E offers significant protection from the oxidative damage (18 & 19).

Zinc and copper are both beneficial to the eye. These essential trace minerals are necessary for the production of the antioxidant superoxide dismutase (SOD). Zinc itself has been isolated in the retina and has shown to be beneficial in reducing the risk of macular degeneration (20). Low levels of zinc can also affect the lens of the eye by predisposing people to cataract formation (21). SOD is a powerful free radical scavenger that seems to dwindle with age (22&23). Chinese researchers found the concentration of serum zinc and SOD to be lower in patients with macular degeneration (24). Both zinc and copper help protect the eye form the damages of oxidative stress by up-regulating our SOD antioxidant defense system.

Glutathione (GSH) is another strong antioxidant enzyme component found in the eye (25). Loss of glutathione is associated with oxidative injury and cataract formation (26&27). The glutathione system in the eye is almost solely dependent on plasma glutathione levels (28). Therefore, in order to protect the eye against oxidant free radicals it may be prudent to increase plasma levels of glutathione by supplementing (28&29). Oral administration of vitamin E, another potent antioxidant, has been shown to increase glutathione levels in the eye and red blood cells (30).

The trace element Selenium is another significant constituent of glutathione. Selenium levels were found to be deficient in patients with cataracts suggesting a defect in the antioxidant system that protects eye from oxidative damage (31).

Vitamin A (retinol) and beta-carotene (provitamin A) have been known for centuries as nutrients necessary for ideal vision and often used for night blindness and other diseases of the eye (32). Vitamin A is found in the eye and deficiencies can lead to bilateral painless retina and cornea disorders (33&34). Beta-carotene supplements can be given at high doses in order to alleviate vitamin A deficiency (35).

Lutein and Zeaxanthin are carotenoids found in the human eye (32). Lutein and zeaxanthin, with their metabolites, are antioxidants protecting the macula from damage due to short -wavelength visible blue light (36). Supplementation with lutein and zeaxanthin significantly decreased the amount of blue light reaching the most vulnerable tissues affected by macular degeneration {photoreceptors, Bruch’s membrane and the retinal pigment epithelium} (37). Patients with macular degeneration were found to have lower serum and retina levels of lutein and zeaxanthin (38) and when dietary intake of these carotenoids were higher, the risk of macular degeneration decreased (39).

Bilberry and grape seed extract are flavonoids with powerful antioxidant properties (40 &41). As previously discussed oxidative stress may contribute to disorders of the eye (1-3). In French studies polyunsaturated fatty acid peroxidation was inhibited when grape seed extract was added (41). Bilberry was found to have a positive effect on various forms of retinopathy and may help reduce retinal hemorrhage associated with diabetes (42). Bilberry also helps improve visual acuity and stabilize myopia (43).

CoQ10 (ubiquinone) is a compound that acts as a free radical scavenging antioxidant (44&45). Found in tissue, serum and most cells, CoQ10 helps reduce lipid peroxidation. CoQ10 has also shown the ability to enhance the antioxidant properties of vitamin E (45). Because of its antioxidant properties CoQ10 is effective in limiting the severity of various eye disorders (46).

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