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Menopause Formula 120 cap

Menopause Formula 120 cap

Code: 827021
Price: USD $18.12
Shipping Weight 0.60 pounds
Category: Professional
Manufacturer: Rx Vitamins
Mfr Code: 1300
NDC: 708429800903

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Product Description
For The Mature Womans Changing Life

During a womans natural mid life changes, her bodys nutritional requirements increase. The Menopause Formula is a delicate combination of nutritional cofactors and adaptogens specially formulated to support her changing metabolism.

The Menopause Formula provides Gamma Linolenic Acid, which is an essential fatty acid derived from evening primrose oil, a soy isoflavonoid concentrate, and Suma, an herbal adaptogen.

This scientifically designed formula addresses the nutritional needs associated with a womans maturing years.

Per 3 caps:
Calcium Hydroxy-Apatite 1000 mg
Magnesium 500 mg
Isoflavonoid Complex 250 mg
Suma 250 mg
Vitamin E 200 i.u.
Vitamin B6 50 mg
Boron 3 mg
Gamma Linolenic Acid 100 mg

Suggested Use: 1 cap three times daily with meals.

Menopause is a word from Greek meaning, "end of the monthly". It is often referred to as the change of life. It's a time in a woman's life when she stops ovulating and her menstrual cycle becomes increasingly irregular and eventually stops (1). Menopause is a natural process of aging. It is not a disease, as some people perceive it. The most significant consequence of menopause is the reduction of estrogen and progesterone levels, which can drop by 75%. There are many symptoms associated with menopause such as hot flashes, vaginal dryness, loss of libido, irritability, depression, anxiety, weight gain, loss of energy and many more (1, 2). However, the most important medical significance is the increased risk to osteoporosis and heart disease (1). As an alternative to drug therapy, more and more women are using nutritional supplements and phytonutrients (plant based nutrients) to help them in this time of transition. Menopause should be the start of a new phase of life that women enjoy, not a time when they experience numerous medical problems and declining health. Reducing the risk factors to medical problems can be achieved with a good quality lifestyle, smart diet, nutritional supplements, exercise and if necessary, hormone replacement therapy (2).

Active Ingredients

Calcium supplementation is extremely important for women of all ages. Estrogen and progesterone play an important role in bone remodeling (bone growth) and resorption (removal of bone tissue). As these hormones decrease the potential for osteoporosis increases. Calcium supplementation can augment the positive effect of estrogen on bone mass and may actually help increase bone density (3). Calcium also has the ability to suppress bone resorption by regulating parathyroid hormone (PTH) secretion (4). An imbalance PTH has been shown to speed up bone resorption (5). Even though they are advised to take calcium in their early years, women can also benefit from supplementation after menopause (6, 7) (8). Supplementing with calcium at 1,000mg per day has been shown to reduce hip and vertebral fractures in elderly women (6). Another critical factor to consider is what type of calcium to use. Research data has demonstrated that calcium from hydroxyapatite is more bio-available and better absorbed than other forms of calcium supplements (9, 10). Hydroxyapatite, consisting of whole bone proteins, numerous minerals including calcium, phosphorous, silicon, and other organic compounds, is the actual substance that makes up much of the bone's structure (5). A significant British study was carried out on post-menopausal women with accelerated bone loss and severely impaired calcium absorption. The results showed the group supplementing with calcium hydroxyapatite had a notable 12% increase in bone thickness, while the group supplementing with calcium gluconate had no change (11). Numerous studies have demonstrated that calcium hydroxyapatite supplementation is an excellent way to help reduce the risk factors to osteoporosis (9-12).

Magnesium is an essential mineral for normal skeletal development. Approximately 60% of the body's magnesium is located in bone (13). Magnesium activates the enzyme alkaline phosphatase necessary for the regulation of bone resorption (14). Several studies have shown that the population in general is deficient in magnesium and this may contribute to bone degeneration as people age (15, 16). Magnesium deficiency can lead to imbalances in parathyroid hormone (PTH) and adversely affect all aspects of bone growth (17). Among other things, magnesium helps to regulate calcium uptake and metabolism (5, 18). In a 2-year study on postmenopausal women, magnesium supplements helped to reduce the risk of fractures and resulted in a significant increase in bone density (18). Both calcium and magnesium supplements were shown to help reduce the risk of bone loss in postmenopausal women (19).

Isoflavone Complex found in soy products contains phytochemicals that exhibit numerous beneficial health effects (2, 20). Soy isoflavones have a wide range of hormonal and nonhormonal activities that may be advantageous to women as they experience menopause (21, 22).

These phytochemicals have a weak estrogenic effect and can benefit both premenopausal and postmenopausal women. In menopause, when estrogen level is low, phytoestrogens can have a net increase in estrogenic activity (2). Because soy has phytoestrogen activity, it has shown to be helpful in reducing hot flashes and vaginal dryness in menopausal women (21, 23, 24). In addition to the improvement in hot flashes, various studies indicate that soy isoflavones may decrease the risk of cardiovascular disease by lowering blood pressure, altering LDL cholesterol receptor activity, reducing LDL oxidation, lowering total cholesterol and elevating HDL cholesterol (23, 25-27).

The phytoestrogen activity of soy isoflavones has also shown the ability to reduce the risk of bone loss in postmenopausal women (23, 28). In a 6-month clinical trial, supplementing with soy isoflavones demonstrated a significant increase in both bone mineral content and density of the lumbar spine (27). It has been postulated that supplementing with soy isoflavones may reduce the risk factors to many degenerative conditions associated with aging (23). Suma is an extract from the Pfaffia Paniculata plant found in the Atlantic rain forest of Brazil. It is sometimes known as Brazilian ginseng. This herb has been called a true "adaptogen".

Adaptogens are compounds that are believed to help the body adjust to a stress or act as a nonspecific tonic. Dr. Milton Brazzach, head of the pharmaceutical department at the University of Sao Paulo Brazil, has researched Suma quite extensively. While studying Suma he isolated a plant sterol known as sitosterol. He theorizes the sitosterols in Suma regulate estrogen production while maintaining normal endocrine metabolism. This in turn prevents the accumulation of excess levels of circulating estrogen. This balancing of estrogen may help reduce some menopausal symptoms.

Vitamin E is well known for its ability to reduce the risks of heart disease(29) and postmenopausal women are seen to be a greater risk to heart disease than premenopausal women (1, 2). Vitamin E is the name given to a group of tocopherols and tocotrienols of which alpha-tocopherol has the widest natural distribution and greatest biological activity (5). The method of action for vitamin E is its ability to donate electrons to lipid peroxyl and other radicals, thereby stopping the chain reaction of free radical-caused damage to cell membranes (30). Because atherosclerosis and heart disease may be the result of free radicals and LDL cholesterol peroxidation, antioxidant supplements can be beneficial to any cardiovascular program (31).

Supplementing with vitamin E has been shown to reduce lipid peroxidation and the risk factors for atherosclerosis and coronary heart disease (29, 32, 33). There are nearly three thousand published research papers on the antioxidant effects and benefits of vitamin E. However, it is very important to understand that natural source vitamin E (d-alpha tocopherol) has been shown to have higher biological activity and greater tissue uptake than synthetic vitamin E {dl-alpha tocopherol}(34, 35). Australian and American studies have shown that supplementing with vitamin E is a cost-effective method in dealing with the risks of atherosclerosis and heart disease (36).

Vitamin B-6 may help women with menopausal symptoms of depression, anxiety and cardiovascular risks. Vitamin B-6 is essential for the metabolism of tryptophan and the synthesis of serotonin (14). The neurotransmitter serotonin, which provides us the sense of well being, is very much dependent on vitamin B-6 and supplementing with B-6 has been shown to raise serotonin levels (37). Of course, raising serotonin levels is the method of action for numerous antidepressant medications. Elevated homocysteine can also present problems for postmenopausal women. Homocysteine is an amino acid produced by the catabolism of methionine (14). Years of research has shown that high levels of plasma homocysteine is associated with an increased risk to heart disease, strokes and neuropsychiatric disturbances (14, 38-42). Elevated homocysteine may be due to genetic defects in the methylation cycle and inborn errors of sulfur-containing amino acid metabolism (5, 40, 43). However, numerous researchers have identified deficiencies of vitamin B-6 as a contributing factor to elevated homocysteine levels (40, 43-45). It has been demonstrated that supplementing with vitamin B-6, above the recommended levels, can help reduce elevated homocysteine levels (41-43, 46).

Boron is a naturally occurring non-metallic chemical element usually found in various fruits and vegetables. Studies show that dietary boron is important for hormone balance and skeletal function (47). Deficiencies of boron have been linked to changes in calcium metabolism affecting bone formation and maintenance (48). These negative changes were enhanced by a magnesium deficiency. Boron supplementation has been reported to regulate plasma estradiol levels and reduce urinary calcium excretion in postmenopausal women (47, 49). Consequently, it is suggested that increasing boron intake may reduce bone loss associated with menopause.

Gamma Linolenic Acid (GLA) is a fatty acid synthesized from the essential fatty acid linoleic acid. An imbalance of GLA will contribute to elevation of pro-inflammatory prostaglandins, leukotrienes and thromboxanes. These inflammatory hormones can be a precursor to platelet aggregation, which can eventually lead to heart disease and numerous inflammatory conditions.

Supplementing with GLA will help balance essential fatty acids. (5)

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