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Formula FM 60 cap

Formula FM 60 cap

Code: 827017
Price: USD $20.59
Shipping Weight 0.50 pounds
Category: Professional
Manufacturer: Rx Vitamins
Mfr Code: 1110
NDC: 708429060604

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Product Description
Advanced Neuromuscular Support

Formula FM is a scientifically designed nutritional supplement that promotes optimal function of healthy muscle tissue, ligaments and tendons.

Formula FM provides malic acid, magnesium glycinate, MSM, boswellin along with other synergistic nutrients to provide nutritional support for the musculo-skeletal system and to promote soft tissue health.

Per capsule:
Magnesium glycinate 100 mg
Vitamin B-6 10 mg
Malic acid 300 mg
MSM 150 mg
Boswellin (standardized boswellia serrata supplying 65% boswellic acids) 100 mg
DL-Phenyalanine 50 mg

Suggested Use:
As a dietary supplement, 2 caplets twice daily with meals for 6-8 weeks, then 1 caplet twice daily or as recommended by your physician or health care professional.

Fibromyalgia is defined as chronic pain in muscles and soft connective tissue surrounding joints (1). The term myalgia indicates muscular pain and any fibromuscular tissues may be affected. However, the most predominant areas of pain are muscles or soft tissue of the neck, shoulders, thorax, low back and thighs (2). According to the American College of Rheumatology this is a rheumatic disorder with widespread pain and of unknown origin (1, 3). Because the etiology remains elusive various drug treatment protocols have been tried with little or no success. Most of these regimens entail the use of antidepressant medications. It is well known that elevated serotonin levels can increase pain threshold (4). However, most fibromyalgia patients do not consider themselves to be depressed and don't want to deal with the side effects of the drugs. Still, the main objective is to reduce the pain and restore normal neuromuscular function (1). To accomplish this goal researchers are now focusing on nutraceuticals as an alternative to pharmaceuticals.

Active Ingredients

Malic acid, a substance found in certain fruits such as apples and apricots, plays a dynamic role in aerobic metabolism of carbohydrates and ATP production. ATP (adenosine triphosphate) is the energy source for muscle cells (1). When ATP concentration in the muscle decline, weakness and fatigue are the result (5). A University of Texas study had fibromyalgia patients supplementing with a combination of malic acid and magnesium. After eight weeks the results were impressive, patients experienced less pain and tenderness and showed considerable improvement in ability to function (6). There is a growing body of evidence that suggests environmental toxins such as pesticides and heavy metals may contribute to the onset of fibromyalgia (7). If heavy metal poisoning is a factor, malic acid may be helpful because it has the ability to chelate and remove toxic minerals (8).

MSM (methyl-sulfonyl-methane) is an organic source of sulfur. Sulfur is necessary to form disulfide bonds. These bonds are the foundation in the production of collagen responsible for the rigidity and strength of connective tissue (9). Sulfur is also a vital component of powerful antioxidants such as N-acetylcysteine and reduced glutathione. Damage from oxidative stress can often lead to inflammation and pain. The body's antioxidant system offers us protection from the insults of numerous environmental toxins. The results of several studies showed that when supplementing with MSM, joint pain had decreased significantly and mobility was enhanced (10).

Magnesium is a component of enzymes required for the synthesis of ATP and for the release of energy from ATP (1). If the concentration of muscle ATP declines, eventually muscle fatigue will set in (5). Magnesium is also a constituent of enzymes involved in muscle contraction(1) and deficiencies may lead to inadequate muscle function. European researchers have found magnesium deficiency to be associated with fibromyalgia and muscle pain (11). As previously mentioned, supplementing with magnesium in combination with malic acid was found to be beneficial for fibromyalgia patients (6). Magnesium supplementation can often lead to diarrhea and like most minerals it is difficult to absorb. Attaching magnesium to an amino acid, such as glycine, will allow the magnesium to be absorbed as an amino acid rather than the normal mineral ion. Magnesium glycinate was found to be more bioavailable and better tolerated at therapeutic doses than was magnesium oxide (12).

Boswellin is a traditional ayurvedic medicine from the Boswellia serrata plant. Boswellic acids, the biologically active ingredients, are shown to be powerful inhibitors of leukotriene production (13). Leukotrienes are potent mediators of pain and inflammation. Another benefit boswellin offers is the ability to reduce pain and inflammation without the gastrointestinal side effects caused by most NSAID's (14).

DLPA (dl-phenylalanine) is an essential amino acid shown to inhibit the degradation of enkephalins (15). Enkephalins are pentapeptides produced in the brain, creating analgesic effects by binding to opiate receptor sites involved in pain perception (1). With this action the threshold for pain is increased. The mechanism for DLPA seems to be its ability to block the activity of the enzyme carboxypeptidase (16). This enzyme degrades the morphine-like enkephalins thereby causing the pain threshold to decrease. European studies have demonstrated that while blocking carboxypeptidase activity DLPA supplementation was able to forestall the incidence of acute pain by keeping enkephalin levels elevated (17, 18).

Vitamin B6 (pyridoxine) is involved in numerous metabolic functions including amino acid metabolism and the regulation of serotonin. The neurotransmitter serotonin has been implicated as a pain mediator(4) and studies have shown fibromyalgia patients had significantly lower serum concentrations of serotonin than did healthy subjects (19). This is probably the reason antidepressant medications are effective for a few people. Vitamin B6 supplementation has shown the ability to raise serotonin concentrations and compared favourably to some medications for relieving pain (20). A large amount of the body's vitamin B6 stores are found in the muscle(21) and deficiencies are known to cause imbalances in magnesium metabolism (22). Of course magnesium deficiencies can also cause muscle pain and fatigue.

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