The Bone Density Formula is a physician formulated dietary supplement which provides calcium, magnesium and boron - all as soluble citrate compounds.
Vitamin D and vitamin C have been added to the formula to maximize the absorption and utilization of the calcium and magnesium and to enhance bone density.
Six capsules contain:
Calcium (as a citrate), 1500 mg
Magnesium (as a citrate), 500 mg
Vitamin C (as ascorbic acid), 200 mg
Boron (as a citrate) 3 mg
Vitamin D (as a cholecalciferol) 200 I.U.
As a dietary supplement, take three to six capsules daily or as recommended by your health care professional.
Osteoporosis is a condition in which bone mass is lost, causing bones to become fragile and susceptible to fracture. With more than 28 million Americans at risk, osteoporosis occurs most frequently in elderly, post-menopausal women, but men also suffer from this disease. It leads to 1.5 million fractures each year with the majority being vertebral and hip fractures (1).
The pathogenesis of this disease can be multi-factorial and may be due to poor lifestyle habits, dietary and nutritional deficiencies, thin body build, prescription drug reactions, amenorrhea in younger women and of course menopause in middle aged women (2). This disease can progress without any symptoms or warning signs. Most people have no idea about their problem until they fracture a bone. By this time they have already lost 30-40% of bone mass. The process of bone loss may begin as early as 30 years of age for some people.
Calcium is important for bone formation, in fact 99% of the body's calcium is found in the bones and teeth (3). The standard American diet of today does not supply us with enough calcium to prevent bone loss and most experts believe it is necessary to supplement (4). It may be essential to begin supplementing with calcium well before women reach menopause in order to reduce the risk factors to osteoporosis. According to most studies the recommended dose is between 1,000 and 1,500 mg per day (5). The type of calcium supplement is also critical. In several studies absorption from calcium citrate was found to be significantly higher than calcium carbonate (6, 7).
Furthermore calcium citrate reduced bone resorption (bone loss) by inhibiting serum immunoreactive parathyroid hormone (PTH) (8). With people predisposed to kidney stones, some types of calcium may increase their risk to calcium oxalate stone development. However, in a study at the University of Texas, calcium citrate supplementation did not increase the risk to stone formation (9).
The importance of calcium for bone structure is well documented. However the other minerals, vitamins and proteins are as equally as important.
Magnesium is an essential mineral for normal skeletal development. Approximately 60% of the body's magnesium is located in bone (10). Magnesium activates the enzyme alkaline phosphatase necessary for the regulation of bone resorption (11). Several studies have shown the Standard American Diet is deficient in magnesium and may contribute to bone degeneration (12). Magnesium deficiency can lead to imbalances in parathyroid hormone (PTH) and adversely affect all aspects of bone growth (13). Oral magnesium supplementation has been shown to curb bone resorption in young adults thereby reducing the risk factors to osteoporosis as they age (14).
Vitamin C (ascorbic acid) is a major component of collagen, the connective tissue that makes bones strong and flexible instead of brittle (3). Collagen contains about one-third glycine and onethird proline and hydroxyproline. Vitamin C is required for the hydroxylation of proline in collagen synthesis. Hydroxyproline is almost exclusively associated with collagen (3). According to Dr Robert Cathcart, developer of the artificial hip, decalcification of bone is not the exclusive cause of osteoporosis. Dr. Cathcart says deficiencies of magnesium and vitamin C may actually result in over-calcification of bone tissue making the bone brittle and susceptible to fracture. Postmenopausal women who were supplementing with vitamin C had higher bone mineral density than did women who were not supplementing (15).
Boron is a naturally occurring, non-metallic chemical element usually found in many fruits and vegetables. Studies show that dietary boron is important for hormone and skeletal function (16). Deficiencies of boron have been linked to changes in calcium metabolism affecting bone formation and maintenance (17). These changes were enhanced by a magnesium deficiency.
Boron supplementation has been reported to regulate plasma estradiol levels and reduce urinary calcium excretion in postmenopausal women (16). Consequently, it is suggested that increasing boron intake could reduce bone loss associated with menopause. In men, boron has shown the capacity to increase testosterone, which can then influence the bone building osteoblast cells (18).
Vitamin D3 (cholecalciferol) and its active metabolite 1,25(OH)2D3 (Calcitrol) are wellestablished regulators of bone mineral balance (3). Vitamin D3 is necessary to ensure proper serum levels of calcium and phosphate. This is essential for regulating bone growth and regeneration. Reduced serum concentration of vitamin D was noticed in elderly women in northern climates with little or no exposure to sunlight. This put them at higher risk for bone loss (19). Younger adults had a significantly higher concentration of vitamin D than did elderly population (20). Clinical trials have demonstrated that supplementing with vitamin D3 can help improve bone density of the spine and speed up the healing time of fractures (19) (21).
Diet and lifestyle habits are critical when it comes to preserving bone mass. The standard American diet consisting of fast foods, soft drinks and caffeine is sadly deficient in vital nutrients necessary to prevent osteoporosis and may actually speed up the process of bone loss. However our diet, no matter how good it is, does not provide us with sufficient nutrients to achieve and maintain optimal health. This is especially true when it comes to maintaining bone density. Therefore supplementation may be essential to maintain good bone health (1).