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Anti Oxidant 90 cap

Anti Oxidant 90 cap

Code: 827004
Price: USD $24.72
Shipping Weight 0.50 pounds
Category: Professional
Manufacturer: Rx Vitamins
Mfr Code: ANTI7
NDC: 708429140900

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Product Description
Maximum Protection Against Free Radicals

The Antioxidant Formula is a scientifically designed super-antioxidant system which provides maximum defense from the effects of free radicals.

Each nutrient provides a unique protective action; together, they work synergistically to neutralize free radicals.

The Antioxidant Formula combines traditional antioxidant nutrients beta carotene, vitamin C and vitamin E with new and exciting, l-glutathione and a phytonutrient blend of broccoli, tomato and spinach.

Three capsules provide:
Vitamin C 500 mg
Beta Carotene 25,0000 i.u.
Phytonutrient Blend:
Broccoli 10:1 50 mg
Spinach 10:1 50 mg
Tomato 50 mg
Citrus Bioflavonoid complex 50 mg
Vitamin E 200 i.u.
Selenium 50 mcg
Zinc 15 mg
N-acetyl-cysteine 15 mg
Bilberry 10 mg
L-Glutathione 10 mg
Wild Grape Seed extract 10 mg

Suggested Use:
Take three capsules daily with meals.

Free radicals are any molecules with an unpaired electron. These molecules are highly reactive and if not eliminated will contribute to dangerous chemical reactions (1). Free radicals, however, are a normal by-product of cellular metabolism (2). Food, drugs, endurance exercise, cigarette smoke and environmental pro -oxidants can also initiate the production of free radicals (3-5). The body compensates for free radicals by generating enzymes and antioxidants. If there is a deficiency or an imbalance in the enzymes or antioxidant system, excessive free radical production will cause oxidative stress and serious cell damage (6).

Oxidative stress has been implicated in most inflammatory and degenerative diseases including: cancer, heart disease, strokes, arthritis, diabetes, Parkinson's disease, Alzheimer's disease, MS, ALS, cataracts, macular degeneration and endometriosis (3, 7, 8). One of the most severe consequences of oxidative stress is damage to mitochondrial DNA (9). The mitochondria is the "powerhouse" of the cell where cell respiration and ATP synthesis occurs. Mitochondrial DNA damage due to oxidative stress is a primary cause of aging, apoptosis (cell death), inflammatory processes and the genesis of most diseases (9-11).

Vitamins C and E, phytonutrients such as flavonoids and carotenoids and other compounds including N-acetylcysteine (NAC) and selenium have powerful antioxidant effects and protect against oxidative stress (12-14). Reducing oxidative stress by supplementing with antioxidants can lessen the risk factors for cancer, heart disease and age-associated decline in immune function and infectious complications in the critically injured or sick patient (15) (14).

Active Ingredients

Vitamin C (ascorbic acid), found naturally in fruits, vegetables and grains, is a water soluble antioxidant and essential for numerous metabolic activities including collagen synthesis, degradation of tyrosine, synthesis of epinephrine from tyrosine, formation of bile acids, the absorption of iron and inhibition of nitrosamines during digestion (6). Because humans lack the enzyme L-gulonolactone oxidase we cannot synthesize vitamin C and must obtain it directly from the diet (6). In a study performed by

Bruce Ames at the University of California, Berkeley vitamin C was found to be one of the most powerful antioxidants in human plasma and helped suppress the degenerative processes caused by oxidative stress (16). Oxidative damage to cellular DNA may be in part due to the up-regulation of an enzyme known as 8-oxo-2'-deoxyguanosine (8-oxodG). Vitamin C was able to reduce levels of 8-oxodG and initiate DNA repair enzymes, thereby protecting cellular DNA from oxidative damage by a non-scavenging antioxidant effect (17). Recent scientific research has shown that increasing the intake of vitamin C will help reduce oxidative stress and the risk of most degenerative diseases (18).

Beta-Carotene, found in many fruits and vegetables, is a carotenoid precursor to vitamin A. Beta- carotene is considered an antioxidant that minimizes damage caused by free radicals (1). Beta-carotene has the ability to stabilize and quench cell damaging organic peroxide free radicals and complements the antioxidant properties of vitamin E (6). Supplementing with betacarotene has been shown to increase the antioxidant defence system and protect the mitochondrial DNA from oxidative damage (19-21). A British study found that when plasma concentrations of beta-carotene was high, the recovery from oxidative damage was enhanced (22).

Phytonutrients are chemicals or compounds derived from plant sources and exhibit powerful antioxidant properties (1). Such phytochemicals include indole, isothiocyanate, phytosterol, polyphenol, saponin, phenolic acids, protease inhibitors, carotenoids, capsaicin, lignins and triterpenoids. The method of action for these phytochemicals appears to be their DNA repairing cytosolic proteins and the ability to decrease oxidative stress by up-regulating the powerful antioxidant glutathione (23, 24). Carotenoid and indole compounds found in spinach, broccoli and tomatoes have been shown to modify P-450 liver detoxification enzymes and inhibit tumor cell growth (25-28). Antioxidant-rich phytonutrients have been well researched and can help forestall cell death and help reduce the aging process due to oxidative damage (29).

Citrus bioflavonoids are phytochemicals that manifest numerous antioxidant characteristics (30, 31). Oxidative stress, mediated by reactive oxygen species (ROS), has been implicated in most degenerative diseases. Flavonoids, found in many fruits and vegetables, are known to be effective in scavenging free radicals by interfering with ROS, therfore protecting cells from oxidative damage and reducing the risk factors to most degenerative conditions (32 &33).

Vitamin E is the name given to a group of tocopherols and tocotrienols of which alpha-tocopherol has the widest natural distribution and greatest biological activity (6). Vitamin E has numerous physiological functions such as its antioxidant properties, promoting cell membrane integrity, preventing red blood cell hemolysis (destruction) and improving immune response (1, 34). The method of action for vitamin E is its ability to donate electrons to lipid peroxyl and other radicals, thereby stopping the chain reaction of free radical-caused damage to cell membranes (34). Vitamin E is undoubtedly the most widely researched antioxidant nutrient and well accepted for its ability to protect cell membranes from peroxidation damage due to free radical reactions (35).

There are nearly three thousand published research papers on the antioxidant effects and benefits of vitamin E. However, it is very important to understand that natural source vitamin E (d-alpha tocopherol) has been shown to have higher biological activi ty and greater tissue uptake than synthetic vitamin E {dl-alpha tocopherol}(35, 36).

Selenium, an essential trace mineral, is required for normal pancreatic function and lipid absorption. It is also a major constituent of the antioxidant enzyme glutathione peroxidase. Selenium works synergistically with vitamin E in reducing oxidative stress due to lipid peroxidation (6). Glutathione is a tripeptide of glutamic acid, cysteine and glycine (1). Glutathione, with its major component selenium, forms glutathione peroxidase (GSH) to control lipid peroxidation before damage to cell membrane occurs (6).

Supplementing with N-acetylcysteine can also help control the depletion of intracellular GSH (37). N-acetylcysteine (NAC), the acetylated derivative of the amino acid cysteine, is a building block in the synthesis of glutathione (14). Oral supplementation with NAC increased WBC glutathione levels by 30% (38). NAC has also proven beneficial in reducing oxidative damage to cells of the lung and optimizing liver detoxi fication enzyme activity (39, 40).

Zinc is involved in most metabolic pathways and is a cofactor of several enzymes including superoxide dismutase, lactate dehydrogenase and alkaline phosphatase (1, 6). Superoxide dismutase (SOD) is a powerful antioxidant that destroys the highly reactive form of oxygen known as superoxide. Superoxide is created when neutrophils respond to harmful bacteria and formed in the red blood cells by the auto-oxidation of hemoglobin to methemoglobin and by the action of different enzymes. Superoxide is first converted to hydrogen peroxide (H2O2) by SOD and then H2O2 is eliminated by the actions of enzymes catalase and glutathione peroxidase (GSH). (6) In order to maintain adequate levels of SOD and GSH it is critical to consume adequate amounts of selenium and zinc (41, 42).

Bilberry and grape seed extracts contain flavonoids, which exhibit powerful antioxidant properties (43, 44). In French studies, lipid peroxidation was inhibited with grape seed extract (43). And a British study demonstrated that serum antioxidant activity was increased after supplementing with grape seed extract capsules (45). The benefits of antioxidant therapy are numerous with research now demonstrating the advantages of using a mixture of antioxidants to reduce oxidative damage and the risks of multiple organ dysfunction and degenerative diseases (13, 14). These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

*Activin is a trademark of the Interhealth Company.

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