Cytochrome P450 is a phase I detoxifying enzyme complex in the liver that supports healthy estrogen metabolism and has been shown to increase the production of 2-OHE.
Indole-3-carbinol (I3C), naturally found in vegetables including broccoli, brussels sprouts and cabbage, induces cytochrome P450 and phase I detoxification enzymes and also supports phase II detoxification enzymes.
A double blind, placebo-controlled study involving 60 women supplementing with indole-3-carbinol resulted in a favorable shift in estrogen metabolism.
Additional clinical trials involving human volunteers demonstrate that I3C has the ability to promote healthy 2-OHE and 16alpha-OHE metabolism, providing a potential mechanism for breast health support.
In an in vitro study conducted at the University of California at Berkeley, I3C moderated cellular enzyme function. This maintained healthy cellular metabolism in a culture of human breast cells.
Furthermore, a placebo-controlled trial indicated that I3C supports cervical cell health as a result of healthy estrogen balance. By enhancing cytochrome P450 enzymes and others, including glutathione-s-transferase, I3C has also been shown to support various tissues and to scavenge free radicals.
In recent years, I3C has shown a promising ability to support prostate cell metabolism. In the stomach, I3C is converted to various active metabolites, most notably diindolylmethane (DIM), believed to be responsible for the health benefits associated with I3C.
Indole-3-carbinol, the powerful phytochemical found in cruciferous vegetables, provides breast, cervical and prostate cell support by activating detoxification enzymes, promoting healthy estrogen balance and cellular metabolism, and scavenging free radicals.
Ingredients per vcapsule: Indole-3-carbinol 400 mg
Other ingredients: hypo-allergenic plant fiber
Suggested use: 1-2 capsules per day, in divided doses, with meals.
Warning: Not to be taken by pregnant or lactating women.