SAMe is utilized by almost every cellof the body and that is why it has such a wide variety of benefits.
SAMe is used by the body in the following metabolic pathways:methylation, synthesis of polyamines, and trans-sulphuration.Methylation is involved in protection or regulation of other moleculessuch as DNA and homocysteine.In Chinese medicine the liver is thought of as the seat of emotionand compromised liver function is thought to be involved inmood. Research has shown SAMe as being of benefit in loweringelevated liver enzymes.
It is suspected that SAMe protects synovial cells by reversingglutathione depletion, thereby being beneficial for compromisedjoint function and degeneration. Studies have shown that duringjoint degeneration the synovial fluid may contain damagingcytokines (TNF) and free radicals.
In addition, SAMe may protect proteoglycans (protein cells,composed of keratin and chondroitin sulfate) and chondrocytes(cartilage cells, that make proteoglycans and collagen) the componentsof the spongy tissues between joints called cartilagethat breaks down during joint degeneration.
For optimal metabolism and utilization of SAMe, it should betaken with B6, B12 and folic acid.
As a dietary supplement, 1 to 2 tablets, one to four times perday, between meals or as directed by a healthcare professional.
Serving Size: 2 Tablets
Servings Per Container: 10
Amount Per Serving:
S-Adenosylmethionine 400 mg
Other ingredients:Cellulose, mannitol, hydroxypropyl methylcellulosephthalate, citric acid, sodium starch glycolate, glyceryl triacetate,croscarmellose sodium, stearic acid, silica, titanium dioxide, yellow ochre .