No other negative drug interactions are known for CoQ10, though a number of medications are thought to interfere with CoQ10 synthesis or function in the body, including statin medications, tricyclic antidepressants, and oral hypoglycemic agents. To prevent side effects or the depletion of CoQ10 in body tissues, many health experts recommend supplementing CoQ10 at dosages ranging from 30 to 400 mg per day in people taking the following drugs:
Cholesterol lowering drugs, such as atorvastatin (Lipitor); gemfibrozil (Lopid); lovastatin (Mevacor); pravastatin (Pravachol); simvastatin (Zocor), etc.
Beta-blocker drugs used in angina, high blood pressure, and heart arrhythmias, such as acebutolol (Sectral); atenolol (Tenormin); carteolol (Cartrol); metoprolol (Lopressor, Toprol XL); penbutolol (Levatol); propanolol (Inderal); timolol (Blocarden), etc.
Phenothiazine drugs used in various psychiatric disorders such as chlorpromazine (Thorazine); fluphenazine (Permitil, Prolixin); mesoridazine (Serentil); trifluoperazine (Stelazine); etc.
Tricyclic antidepressants, such as amitryptaline (Elavil, Endep); desipramine (Norpramin, Pertofrane); doxepin (Adapin, Sinequan); imipramine (Imavate, Presamine, Trofinil); nortryptaline (Aventyl, Pamelor); protryptaline (Vivactil); etc.
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