A generous amount of L-carnitine is required for health and proper growth. While deficiency of L-carnitine is not a common diagnosis, the proper daily intake for optimal health is not known. Common indications of carnitine deficiency are
1. systematic muscle weakness, myopathy along with some chronic pain. This is sometimes genetic in origin but can be brought about by malnutrition or simply old age .
2. slow recovery from exercise stress .
3. hyperthyroidism which includes developing osteoporosis and age related bone loss4.
4. some forms of chronic diabetic neuropathy , where patients are deficient in L-carnitine.
5. carnitine insufficiency is a contributing factor to muscle weakness during renal dialysis and deficiency is sometimes brought about by liver disease.
6. vegetarian diets; L-carnitine is found in only low amounts in most fruits and vegetables.
Each capsule provides 500 mg (RDI is unknown) of acetyl-L-carnitine. This form of carnitine has been shown effective at traversing the intestinal barrier into the bloodstream and to arrive in effective amounts within the inner matrix of the mitochondria. The mitochondria is the important, sub-cellular organelle of energy production, as ATP, and exchange (GTP) from lipids.
Diet supplementation with L-carnitine is important - People on strict vegetarian diets may not be able to ingest an adequate amount of L-carnitine, for only a few fruits & veggies contain significant amounts. This compounds the problems of sedentary folks on fruit and vegetable diets, for the muscles of obese individuals have drastically reduced ability to oxidize fatty acids which is partly due to both low levels of L-carnitine and low activities of CTP I and II in these muscles . It is well known, from several independent human studies, that obesity is a strong correlate with type II diabetes. Supplementing the diet with L-carnitine can help avoid type II diabetes, Parkinsonís and a range of cardiovascular diseases.
Probably the most exciting development in L-carnitine supplementation is the effect this ingredient has on muscle strength. This is supported by clinical findings of L-carnitine supplements delaying or even preventing cardiovascular disease8 and also reducing hospital time for diabetics. Early intervention with 1.5 to 3 grams of L-carnitine, daily, significantly reduces diabetic neuropathy5. Bone re-adsorption is inhibited and bone growth stimulated by L-carnitine4. At high concentrations L-carnitine suppresses the release of tumor necrosis factor α (TNF-α) and interleukin-12, both factors signaling for osteo-bone cell senescence and death. It even reduces the binding of dexamethasone to bone cells, thus reducing the seriousness of a side-effect of this important drug.
Each capsule contains 500 mg of acetyl-L-carnitine, with small amounts of cellulose, silica and magnesium stearate; excipients to retard moisture spoilage.
Two tablets daily with food.
Consult your healthcare professional.