This breakthrough Acetyl L-Carnitine & Alpha-Lipoic Acid formula contains two critical nutrients, acetyl L-carnitine (500mg) and alpha-lipoic acid (150mg), to effectively support your vital metabolic functions. These compounds support the bodys own system for the maintenance of cell function as we age, promoting enhanced mitochondrial function coupled with antioxidant protection.
Acetyl L-Carnitine (ALC) and Alpha Lipoic Acid Research
The initial excitement about ALC/alpha lipoic acid (ALA) supplementation began when a team of researchers at UC Berkeley fed elderly rats both nutrients for a period of seven weeks and then compared them with young rats. They were testing the theory that mitochondrial decline is caused by free radical damage. There was already evidence that supplementation with acetyl L-carnitine (ALC) could reverse the age-related decline in mitochondrial activity in rats, increase fatty acid oxidation and boost general metabolic activity. However, the downside to this increased mitochondrial function was that more oxidative damage occurred, so the researchers decided to add the powerful mitochondrial antioxidant alpha lipoic acid (ALA) to the mix to see if they could get the best of both worlds: increased mitochondrial energy output, with reduced mitochondrial damage.
The team of researchers led by Bruce N. Ames, professor of molecular and cell biology at UC Berkeley, fed older rats two chemicals normally found in the bodys cells and available as dietary supplements: acetyl-L-carnitine and an antioxidant, alpha-lipoic acid.
In three articles in the February 19, 2002 issue of Proceedings of the National Academy of Sciences (PNAS), Ames and his colleagues reported the surprising results. Not only did the older rats do better on memory tests, they had more pep, and the energy-producing organelles in their cells worked better. One of the three PNAS articles probes the reasons behind this rejuvenation, concluding that the two chemicals tune up the energy-producing organelles that power all cells, the mitochondria. Both chemicals are normally used in mitochondria.
Mitochondria and Aging
Ames calls mitochondria the weak link in aging. Evidence has been piling up, he said, that deterioration of mitochondria is an important cause of aging. A significant cause of this deterioration, he believes, is the accumulation of destructive free radicals - byproducts of normal metabolism - that disable enzymes and other chemicals. The combination therapy targets mitochondria to get rid of destructive radicals and to boost the activity of a damaged enzyme, carnitine acetyltransferase, that plays a key role in burning fuel in mitochondria.
Supplementation with acetyl-L-carnitine or a combination of acetyl-L-carnitine and alpha-lipoic acid restored the enzymes activity nearly to that found in young rats and substantially restored binding to acetyl-L-carnitine. The acetyl-L-carnitine is protecting the protein and the higher levels are enabling the protein to work, while alpha-lipoic acid knocks down oxygen radicals, Ames said. Each chemical solves a different problem - the two together are better than either one alone.
Serving Size: 1 tablet
Servings Per Container: 60
Amount Per Serving %DV
Calcium 40mg 4%
Acetyl L-Carnitine 500mg *
Alpha-Lipoic Acid 150mg *
Percent Daily Value based on a 2000 calorie diet
*Daily Value not established
This Acetyl L-Carnitine & Alpha Lipoic Acid formula is a powerful combination of two critical nutrients that work synergistically to support your vital metabolic functions. These compounds support the body’s own system for the maintenance of cell function as we age.
Do not use if tamper-evident seal is either broken or missing.
KEEP OUT OF REACH OF CHILDREN.
Product & Usage Information:
Daily Use: Take 1 tablet, 1-4 times daily. Or take as directed by your health care professional.
Inactive Ingredients: Microcrystalline cellulose, stearic acid, modified cellulose gum, magnesium stearate, and colloidal silicon dioxide.
Contains No: yeast, dairy, egg, gluten, soy, wheat, sugar, starch, salt, preservatives, or artificial color, flavor or fragrance. Suitable for Vegetarians.
Contraindications: If you are pregnant, breastfeeding, have any disorder of blood sugar metabolism (such as diabetes), or suffer from any seizure disorder (such as epilepsy), consult your physician before using this product.