The bioactive compounds in cinnamon appear to potentiate insulin activity at the level of the cell receptor for insulin. It has been shown that insulin resistance involves down regulation of insulin signaling characterized by dephosphorylation of the receptor. Enzymes called protein tyrosine kinases (PTPases) are believed to decrease receptor phosphorylation, and increased PTPase activity has been observed in insulin resistant rats. Cinnamon compounds have demonstrated the in vitro ability to inhibit PTP-1 and increase autophosphorylation of the insulin receptor.

HUMAN CLINICAL TRIALS
The effect of cinnamon on glucose and blood lipids levels or cholesterol numbers on people with type 2 diabetes was tested in a recent randomized, placebo-controlled trial. A total of 60 subjects were divided into six groups administered 1, 3, or 6 grams of cinnamon daily, in 500 mg capsules, or equal numbers of placebo capsules.

The cinnamon or placebo capsules were consumed for two periods of 20 days each. Serum glucose, cholesterol numbers such as triglyceride, cholesterol, LDL cholesterol and HDL cholesterol were measured after 20 days, 40 days and again at the end of a 20-day wash-out period, during which neither cinnamon nor placebo was consumed.

In all three cinnamon groups, statistically significant reductions in blood glucose levels occurred, with decreases ranging from 18 to 29 percent. Interestingly, glucose levels remained significantly lower after the 20-day wash-out period (60 days from the study start) only in the group that took the lowest cinnamon dose (1 gram daily). The placebo groups showed no significant changes.

The overall results of this trial demonstrate that cinnamon exerts a beneficial effect on blood glucose and cholesterol numbers lipid levels in people with type 2 diabetes, at daily intakes of 1 gram, and that this low dose is equally efficacious as are the higher doses of 3 and 6 grams.

Each capsule contains:
60 Veggie Caps
Ingredients per capsule:
Cinnamon bark extract ...........125 mg (Cinnamomum cassia auct,)

Ingredients
Best Cinnamon
Cinnamon, a staple ingredient in apple pie, has remained one of the worlds favorite spices throughout recorded history. The evergreen cinnamon tree (Cinnamomum verum), considered to be true cinnamon, is native to Sri Lanka. Chinese cinnamon (Cinnamomum cassia or Cinnamomum aromaticum), the cinnamon most commonly sold in the U.S., goes by the name Cassia. Usage of cinnamon in Chinese medicine is said to date back over 4,000 years. Mentioned in the Bible, cinnamon was imported to Egypt and Europe from the Far East by 500 B.C. In addition to its value as culinary spice, cinnamon has traditionally been utilized as a folk medicine for colds and minor digestive complaints. True cinnamon and cassia are very similar; cassia has a more pungent flavor.

Recent research has revealed that constituents in cinnamon bark called procyanidin Type-A polymers help maintain the bodys ability to metabolize glucose in a healthy way.* Best Cinnamon Extract is Cinnulin PF®, a patented, water extract of Cinnamon that contains Type-A polymers. Cinnulin PF® is a registered trademark of Integrity Nutraceuticals International and is manufactured under US Patent # 6,200,569.