MSM which provides 1,000 mg of high quality methylsulfonylmethane, offers the following benefits:
•Supports healthy joints and connective tissue
•Patented OptiMSM® brand methylsulfonylmethane used in clinical studies
•High quality; 99.9% pure
Sulfur is a component of many proteins, including those found in collagen, which is found in most connective tissue. It also is a component of hormones, enzymes, and antibodies. Because sulfur is continually used and expended, it must be replenished regularly for optimal health and nutrition. MSM is a biologically active form of sulfur. Moreover, studies suggest that serum MSM levels decrease with age.
Connective tissue serves as the support system for the body, linking, separating, and protecting the body's cells, tissues, and organs. Muscles, blood vessels, tendons, ligaments, cartilage, and bone all contain connective tissue, so keeping connective tissue healthy is important for many body functions, especially joint mobility.
How Does It Work?
MSM is an endogenous cellular metabolite that acts as a sulfur donor in numerous transmethylation reactions and also acts as an antioxidant and free radical scavenger. It may play a role in the synthesis of glutathione. An animal model study found that MSM may have a protective effect on exercise-induced oxidative stress. As a key sulfur source, MSM can promote connective tissue integrity and support the body's normal repair functions. These properties may contribute to MSM's positive effects on joint and respiratory health.
An additional advantage of MSM is its rapid absorption and long period of bioavailability in the body. After the initial dose, MSM may be detected in the blood after only two hours; it is cleared from the blood 400 hours after discontinuing use.
A small placebo-controlled study with 16 patients studied the effects of MSM for six weeks. Using a visual analog scale, patients using MSM showed a 60 percent average improvement in joint health after four weeks and an 82 percent improvement after six weeks. Those on placebo showed a 20 and 18 percent average improvement, respectively. Another double-blind, parallel, placebo-controlled study where thirty patients received MSM statistically improved comfort. Joint mobility showed improvement after two weeks of treatment with MSM.
In a larger randomized, double-blind, placebo-controlled trial, fifty men and women (ages 40 – 76) were given 3 g of OptiMSM brand methylsulfonylmethane or placebo twice a day for twelve weeks to determine MSM's effects on joint health. Using standard patient and physician evaluation methods, MSM was found to provide more support for physical function than placebo (a 12 percent improvement). Blood tests conducted during the trial also found improvements in homocysteine and urine MDA (malondialdehyde).
MSM's role in preserving integrity and mobility in joints has been further elucidated through laboratory testing. An animal study also found that OptiMSM supported the health of articular cartilage and synovial membrane, the soft tissue that lines the joints.
In a multi-center, open label study, 55 subjects, received 2,600 mg of OptiMSM per day for thirty days. Using standard methodologies, results indicated that MSM supported a healthy immune response and improved upper and lower respiratory system function.†10 By week two of the study, energy levels also increased and did so for the duration of the study. MSM was well-tolerated with few side effects.
Most recently, research has demonstrated that OptiMSM brand methylsulfonylmethane may assist with healthy liver functioning. A five-week laboratory study found that supplementing 80 mg of OptiMSM in 1000 ml of drinking water increased concentrations of liver glutathione, and internal sulfur-containing antioxidant with liver protective effects, compared to an unsupplemented diet. This study suggests that MSM may enhance antioxidant functions and assist in detoxification.
MSM provides evidence-based nutritional support for healthy joints and connective tissue. With a long history of use and clinical studies to support efficacy, MSM provides a bioavailable form of sulfur, which is necessary for many body functions.
All colors used are from natural sources.
OptiMSM® is a registered trademark of Cardinal Nutrition for its patented MSM.
Serving Size: 1 Tablet
(methylsulfonylmethane) (OptiMSM® brand)
Cellulose, Modified Cellulose, Titanium Dioxide Color, Magnesium Stearate, Soy Lecithin, Carnauba Wax
Does Not Contain:
Sugar, Salt, Yeast, Wheat, Gluten, Corn, Dairy Products, Artificial Flavoring, Preservatives, Ingredients of Animal origin
Take 1 to 3 tablets daily.
If pregnant, nursing, or taking prescription drugs, consult your healthcare practitioner prior to use.