How Does It Work?
MSM has a variety of mechanisms within the body. Three major mechanisms for supporting healthy joints and connective tissue have been suggested.
•Studies suggest that serum MSM levels decrease with age. Replacing MSM in the body provides additional health benefits, such as building healthy connective tissue including: hair, nails, and joints.
•MSM is a form of sulfur that occurs naturally in the human body. Sulfur is a component of the amino acids methionine and cysteine (cystine) and is an essential element of the body. Amino acids are the building blocks of protein. Proteins help to form muscle tissue, connective tissue, blood transport proteins, blood clotting factors, lipoproteins, visual pigments, and the support structure inside bones. Medical studies have indicated sulfur levels lower than normal in people with unhealthy joints. This can have wide-ranging effects on health.
•DMSO enhances the body's natural anti-inflammatory agent, cortisol. As MSM is a metabolite of DMSO, it is speculated that MSM has this cortisol enhancing property as well. In addition, it is theorized that MSM alters the activity of the immunoregulatory molecules such as prostaglandins and lymphokines. Prostaglandins are hormones that bind to receptors on target cell membranes and can play a role in mediating inflammation. Lymphokines are small protein hormones that inhibit or stimulate cell functions such as normal cell growth and differentiation. Both prostaglandins and lymphokines increase in response to stress and injury and play a role in the body's inflammatory response.
One of the primary physiological roles of glucosamine sulfate is to stimulate the synthesis of the substances required for proper joint function. Glucosamine occurs naturally in the body and is made from glucose and the amino acid, glutamine. Glucosamine sulfate is glucosamine combined with sulfate, which helps the body metabolize glucosamine. Glucosamine sulfate molecules are very small, and this allows them to cross the blood-synovial barrier in the joint and spread from the cartilage matrix to the chondrocytes. Chondrocytes are the cellular building blocks of joint cartilage. Glucosamine sulfate is then used by the chondrocytes to make monosaccharides that form the glycosaminoglycan (GAG) chains of joint cartilage.
Cartilage cushions and protects the joint. An adequate supply of glucosamine helps to keep the joint cartilage strong and lubricated.
The addition of glucosamine sulfate to MSM is an effective combination in supporting joint health. It is proposed that the synergistic combination of these two components provides enhanced benefits.
Evidence from clinical studies has shown glucosamine sulfate (500 mg) should be taken at least two to four weeks to achieve maximum benefits. Therefore, though benefits of MSM may be noticed in the first week of use, MSM with Glucosamine Sulfate should be taken at least two to four weeks to achieve maximum benefits.
Recommendations: One to three UltraCaps daily.
Serving Size: 1 UltraCap Amount/Serving DV
Chloride (from glucosamine sulfate) 78 mg 2
Sodium 50 mg 2
Glucosamine Sulfate (stabilized) 500 mg
MSM (methylsulfonylmethane) 250 mg
Daily Value (DV) not established.
Other Ingredients: vegetable polysaccharide capsule, magnesium stearate, and silicon dioxide.
Contains No: sugar, yeast, wheat, gluten, corn, soy, dairy products, artificial coloring, artificial flavoring or preservatives. This product contains natural ingredients; color variations are normal.
OptiMSM is a registered trademark of Cardinal Nutrition for its patented MSM.
If pregnant, nursing, or taking prescription drugs, consult your healthcare practitioner prior to use.
Very few health hazards or side effects are known in conjunction with proper administration of recommended dosages of MSM. In rare instances, there may be mild gastrointestinal discomfort and loose stools due to intake of greater than recommended doses. If GI upset occurs, it is recommended to decrease the dose. Taking MSM in two or three doses throughout the day with foods also reduces the risk of developing GI upset.
It is not recommended to take MSM close to bedtime as it may cause an increased energy level and possible sleeplessness. It is theorized that MSM mildly inhibits the enzyme acetylcholinesterase. The inhibition of this enzyme allows the neurotransmitter acetylcholine to remain active longer. Acetylcholine can stimulate the nervous system.
Years of clinical use report no interference with prescription medication.
In rare instances, there have been anecdotal reports of MSM causing false positive results in liver function tests. MSM should be stopped four days prior to the test. MSM can be resumed after the liver test is completed. The results of false positive reports have not been shown in a clinical study on MSM. However, we offer this advice as a precautionary measure.
Anecdotal evidence from clinical practice with MSM indicates that MSM may have a mild blood-thinning effect on platelet aggregation. Platelets are blood cells that help in clotting. Excessive platelet formation (aggregation) can be dangerous, as the excessive platelets are associated with heart attacks and strokes. If MSM is taken with prescription blood-thinning medications, this may prolong bleeding and clotting time. This is undesirable in the surgical patient and should be discussed with a licensed healthcare professional.
Very few health hazards or side effects are known in conjunction with proper of administration of recommended dosages of glucosamine sulfate. Mild gastrointestinal effects were reported in rare instances; these effects usually subsided with continued use of glucosamine sulfate. In very rare instances, pruritus or skin reactions were reported. Overall, glucosamine sulfate when used as recommended, is well tolerated with very few adverse reactions.