Lipotropic Complex provides comprehensive transmethylation support for the liver.
How Does It Work?
During transmethylation reactions, methyl groups are transferred from donor to acceptor compounds for modification, restructuring, and detoxification processes. Methyl group donation is needed for the biosynthesis of vitamins, hormones, neurotransmitters, enzymes, antibodies, and the genetic material deoxyribonucleic acid (DNA).
One important example of transmethylation is found in the methionine cycle, which is responsible for the methylation of the amino acid, homocysteine. After the methyl groups convert homocysteine into methionine, it is further converted to S-adenosylmethionine, the major methyl-group donor in other transmethylation reactions in the body. This cycle not only supports healthy homocysteine levels, it also contributes to optimal cellular metabolism, provides sufficient nucleotides for DNA repair, and assists in effective protein synthesis.
The body's primary sources of methyl groups are the nutrients choline, folic acid, and methionine. While the average adult diet contains some methyl-related nutrients, this intake may not be adequate to support healthy transmethylation reactions. Several factors interfere with methyl group donation, increasing the need of a high methyl diet. Most notable are the presence of environmental stress, being overweight, increased body mass index (BMI), reduced resting energy expenditure (sluggish metabolism), and even the aging process. Addressing these factors can promote healthy neurological development, cognitive function, and cardiovascular health.
The following provides recent study findings of the B vitamins contained in Lipotropic ComplexTM dietary supplement and healthy homocysteine support†:
B Vitamin and Study Findings
Laboratory studies have identified a wide range of biochemical reactions that depend on vitamin B6, including amino acid metabolism, the synthesis of nucleic acids, hemoglobin, and the neurotransmitters serotonin, dopamine, norepinephrine and gamma-aminobutyric acid (GABA).
In clinical trials, folic acid was demonstrated to support healthy homocysteine levels in older men and women. Folic acid also supported healthy hearing and skin integrity through homocysteine support.
The effect of oral vitamin B12 in 42 women with low B12 levels was studied over a 6-week period. Clinical measurements were made at the beginning and at the end of the study, and blood samples were collected. Vitamin B12 supplementation increased plasma vitamin B12 concentration and supported healthy homocysteine concentration within the first 2 weeks, remaining stable for the next four weeks.
Until recently the physiological role of magnesium has been essentially ignored. With the development of new technologies to measure the intracellular free concentration of magnesium, there has been an explosion of interest in the molecular, biochemical, physiological and pharmacological functions of magnesium.16 Research has demonstrated that magnesium is vital to methyl group balance and transmethylation reactions.
The importance of the amino acids L-methionine and choline to healthy transmethylation reactions is firmly established. Both amino acids have been clinically studied to promote healthy neural tube development, optimal transmethylation reactions, and homocysteine balance. The table below provides evidence based findings for these amino acids.
Amino Acid and Study Findings
A study of 82,000 adults measured their intake of methionine over a period of 7 years. Methionine intake was inversely associated with increased immune health needs. A recent metabolic study demonstrated that healthy elderly (66-76 y) individuals have increased methionine needs compared to healthy young adults (22-26 y).
Choline plays an important role in the metabolism of homocysteine in humans. In a prospective study of 16,000 women aged 49-70 years, choline intakes were calculated with the USDA database providing the choline contents of common US foods. Choline intakes were statistically significantly associated with healthy homocysteine levels. Adequate intake of dietary choline was also shown to provide lifelong neurosupportive benefits.
Herbal and Nutritional Extracts
As most transmethylation reactions occur in the liver, maintaining healthy hepatobiliary function is crucial. Recent research has identified several methyl-related nutrients known for their liver and biliary support - nutrients that are found in Lipotropic ComplexTM dietary supplement:
Nutrition and Study Findings
Radishes have been shown to contain a variety of chemicals that promote the flow
Research has demonstrated that beet extracts support healthy liver function, including enzyme synthesis, antioxidant activity and phase II detoxification (where amino acids or other nutrients are added to waste products making them water-soluble for excretion via bile or urine).
Supports healthy regulation of bile secretion.
Chionanthus virginicus aids the liver in general and is often used as part of wider health support for the whole body.
The genus Taraxacum has anti-oxidative properties and supports healthy fluid balance.
Milk thistle's liver supportive properties are well-established. Milk thistle supports healthy synthesis of tumor necrosis factor (TNF),TNF-alpha, nitrous oxide, interleukin-6, and interleukin-1 receptor antagonist. Silymarin, the key component of milk thistle, also increases lymphocyte proliferation, interferon gamma, interleukin-4, and interleukin-10 cytokines, in a dose-dependent manner. In a metabolic clinical study, 34 adults aged 21-65 years were randomized to treatment with milk thistle or placebo. After four weeks the milk thistle group demonstrated healthy liver chemistries and immune responses.
Standardized extracts of Chelidonium majus have been shown to support healthy liver function and enhance immune defenses.
Ox bile extract
In a Hungarian study, 800 volunteers were randomized to receive either bile salt supplements or placebo for one to eight weeks. Almost 79% of the treatment group, those receiving bile salt supplements, had healthy skin compared to 25% of the placebo group.
Transmethylation reactions are dynamic processes crucial to human health. The donation of methyl groups requires specific nutritional support. While the average adult diet contains some methyl-related nutrients, these amounts may not be sufficient for optimal outcomes. Lipotropic ComplexTM dietary supplement provides comprehensive transmethylation support for the liver. Choline, folic acid, and methionine act as methyl donors, vitamins B6, B12, and folic acid play roles in homocysteine metabolism, and clinically studied herbs support healthy hepatobiliary function.
Take 1 or 2 capsules three (3) times daily with meals, or as directed by your healthcare practitioner.
Not recommended for use if pregnant or nursing. If taking prescription drugs, consult your healthcare practitioner prior to use.
This product contains natural ingredients; color variations are normal.
ITI evidence-based natural medicines are the only choice of doctors who rely on the fact base of premier science to deliver patient results.
Lipotropic Complex provides comprehensive transmethylation support for the liver by combining phyonutrients and bile salts. Choline, methionine, and silymarin act as methyl donors in hepatic transmethylation reactions. Vitamins B6, B12, and folic acid are required as cofactors for these conversions.
Serving Size: 2 Capsules
Vitamin C 11mg
Vitamin B6 25mg
Folic Acid 100mcg
Vitamin B12 25mcg
Black Radish 133mgInositol 125mg
Fringe Tree 100mg
Milk Thistle 100mg
standardized to contain 2.3 alkaloids
Ox Bile Extract 25mg
Milk Thistle 12mg
standardized to contain 80 silymarin
Gelatin, Ascorbyl Palmitate
Does Not Contain:
Sugar, Salt, Yeast, Wheat, Gluten, Corn, Soy, Dairy Products, Artificial Coloring, Artificial Flavoring, Preservatives.