|Calcium D-Glucarate 90 veg. caps|
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Manufacturer: Integrative Therapeutics
Mfr Code: 146006
Calcium D-glucarate is the calcium salt of d-glucaric acid. Naturally occurring both in the human body and in certain plant sources, supplementation with patented Calcium D-Glucarate has been shown in research studies to support healthy immune system function, promote estrogen metabolism, and enhance the body's detoxification systems through inhibition of beta-glucuronidase.†
How Does It Work?
Calcium D-glucarate plays an important role in the body's natural detoxification processes, specifically by enhancing healthy estrogen metabolism.†
Detoxification refers to the breakdown and excretion of substances that are no longer needed or may be harmful to the body. One of the ways in which the body excretes hormones and toxins is by binding them to glucuronic acid in the liver, and then excreting the compound in bile. This process can be disrupted by beta-glucuronidase, an enzyme produced by intestinal bacteria. Beta-glucuronidase breaks the chemical bonds established between glucuronic acid and the spent hormones or toxins. As a result, the bound toxins (called xenobiotics) can be released and reabsorbed in the body instead of being excreted.
Detoxification in the liver is a two-step process. In Phase I Detoxification, oxidation is used to break down the toxins. In Phase II, a lipophilic (fat-loving) compound is combined with a water-soluble substance which is more easily transported by bile and excreted from the body. Calcium D-glucarate supports Phase II Detoxification by inhibiting the action of beta-glucuronidase.†1-3
By aiding the overall detoxification process in the liver, calcium D-glucarate beneficially affects estrogen metabolism as well.†1 During Phase II Detoxification estrogen is bound to glucuronic acid and this compound is then excreted in bile. As beta-glucuronidase can break the estrogen-glucuronic bond, inhibition of this enzyme by calcium D-glucarate can support healthy estrogen levels in the body and healthy estrogen excretion.†2,3
Calcium D-Glucarate Research
These actions of calcium D-glucarate have been shown to have a beneficial effect on immune system function.† Scientific studies have shown that supplementation supports healthy cell growth, development, and proliferation, particularly in breast and prostate cells.†3-8
In an animal model, a calcium D-glucarate supplemented diet was administered after treatment with a toxin. Supplementation was found to substantially lower beta-glucuronidase levels and increase excretion of toxins. This, in turn, enhanced cellular health and development.†7
Similar results were seen in a six-week clinical trial where participants received an escalating dose of calcium D-glucarate, beginning with 1.5 g and increasing to 9 g per day. The level of D-glucaric acid was measured at baseline and at study completion.8 All groups experienced a significant rise in serum D-glucaric acid over the course of the study.† Serum levels beta-glucuronidase were also measured and found to decrease significantly as the dosage of calcium D-glucarate increased, an indication of the beneficial role of calcium D-glucarate supplementation in the protection of cellular health.†8 Furthermore, calcium D-glucarate was found to be well-tolerated, even at the highest dosage.8
Calcium D-Glucarate supports immune system function, promotes estrogen metabolism, and enhances the body's detoxification systems by inhibiting the activity of beta-glucuronidase.†
Take 1 to 3 UltraCapsTM three times daily with meals, or as directed by your healthcare practitioner.
If pregnant, nursing, or taking prescription drugs, consult your healthcare practitioner prior to use.
How Is It Supplied?
Store at controlled room temperature, 59° to 86°F (15°-30°C).
This product does not contain
This product contains natural ingredients; color variations are normal.
Other Ingredients: vegetable capsule (modified cellulose), modified cellulose gum, and magnesium stearate.