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AM/PM Menopause Formula 60 tabs

AM/PM Menopause Formula 60 tabs

Code: 320071
Price: USD $24.00
Shipping Weight 0.50 pounds
Category: Professional
Manufacturer: Integrative Therapeutics
Mfr Code: 77206
NDC: 871791000155

Free Shipping to All US Addresses

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Product Description
AM Menopause Formula:
Black Cohosh (Cimicifuga racemosa) Root Extract for relief of menopausal symptoms

Note: The black cohosh is wild crafted in the United States.
Ginseng (Panax ginseng) Root Extract Phytosome to support energy levels and relieve menopausal symptoms
Green Tea (Camellia sinensis) Leaf Extract to support women's health and energy levels

PM Menopause Formula:
Black Cohosh (Cimicifuga racemosa) Root Extract for relief of menopausal symptoms

Note: The black cohosh is wild crafted in the United States.
L-Theanine to support relaxation
Valerian (Valeriana officinalis) Root Extract to support better sleep at night
Hops (Humulus lupulus) Flower Extract to support better sleep at night

AM/PM Menopause Formula is a unique dietary supplement to relieve common menopausal symptoms all day and all night. AM/PM Menopause Formula is hormone-free.


Menopause is defined as “permanent cessation of menstruation.” It results when the ovaries decrease production of the sex hormones estrogen and progesterone, and it signals the end of a woman's reproductive ability.

It is estimated that over 5,400 women enter menopause daily in North America. For most women, menopause occurs as part of the natural aging process, usually between the ages of 35 and 58. This hormonal change is influenced by many factors, including genetics, diet, lifestyle, and environmental stresses. “Premature” menopause is sometimes linked to other physical or hormonal disorders. Some women may experience “induced” menopause as a result of surgical removal of the ovaries.

Menopause is not a disease, but a natural event signaling the end of fertility. Menopause-related changes are unique for each woman and may range from mild to severe. In early menopause, some women may experience mood swings, panic attacks, sleep disturbances, depression, changes in tolerance to heat or cold, joint and muscle pain, allergies, and headaches. As production of estrogen decreases, additional menopause-related changes may include irregular menstrual patterns, night sweats, fatigue, vaginal dryness, fluctuations in sexual desire or response, forgetfulness, hot flashes, and weight fluctuations.

The most common menopausal disturbance is the "hot flash" (or "hot flush") - a sudden warm feeling in the face and/or upper body, accompanied by blushing, increased pulse rate, and sometimes perspiration. A cold chill often follows. A few women have only the chill without the flash. The hot flash results from a change in the body's circulation. The usual underlying cause is decreasing or fluctuating estrogen levels.

Hot flashes that occur with drenching perspiration while sleeping are called "night sweats." Night sweats and hot flashes may interfere with sleep. Falling estrogen levels alone can also disrupt patterns of healthy deep sleep. Without adequate sleep that progresses undisturbed through all the sleep stages, women can become tired and irritable. Therefore, fatigue and irritability are considered secondary symptoms that may be alleviated by addressing the underlying cause, which is lack of sleep.

Among the many misconceptions associated with menopause is that mental health problems, such as depression and anxiety, are inevitable as hormone production decreases. In reality, there are no scientific studies to support the belief that natural menopause is responsible for true clinical depression, clinical anxiety, severe memory lapses, or erratic behavior. However, women who have been deprived of sleep because of menopausal night sweats and changes in estrogen levels can feel tired, irritable, and moody. Additionally, the hormone fluctuations, although normal, can be stress provoking, which creates emotional upsets, mood changes, and intermittent anxiety.

Due to the diversity of symptoms related to menopause, a broad-spectrum menopause formula must address hot flashes, improve sleep quality, increase resistance to stress, reduce fatigue, and promote relaxation. The following herbs were chosen for their ability to relieve menopausal symptoms.

How Does It Work?

AM and PM formula:
Black Cohosh and menopause
Black cohosh (Cimicifuga racemosa) has traditionally been used for relief of menopausal complaints, especially hot flashes. Although the exact mechanism of its action has not been fully elucidated, the strongest evidence for the use of black cohosh comes from the results of clinical trials. A series of open clinical studies in more than 800 subjects demonstrated good efficacy of black cohosh extract in relieving hot flashes. Several double blind, placebo-controlled studies also demonstrate that black cohosh extract is beneficial in relieving menopausal symptoms.

The German Commission E monograph for black cohosh does not recommend its use for longer than 6 months, because of the lack of long-term safety data. However, to date, no evidence of toxicity or serious side effects has ever been reported in women.

The primary constituents in Cimicifuga racemosa extract are glycosides, specifically triterpene glycosides that include cimicifugoside, actein, and 27-deoxyactein. The Cimicifuga racemosa extracts used in AM/PM Menopause Formula† are standardized to these triterpene glycosides measured as 27-deoxyactein.

Early research hypothesized that black cohosh exerted estrogen-like effects. Recent laboratory research shows that black cohosh binds to the estrogen receptor; however, it does not affect the luteinizing hormone level and does not exhibit estrogen-like effects. Thus, there is currently no consensus as to the biological effect of this binding. In small, as-yet unpublished human studies, there is indication that Cimicifuga racemosa does not alter estrogen levels and does not change the thickness of the lining of the uterus.

The question of how black cohosh works at the cellular level is currently being addressed in several ongoing research projects. To date, there is no definitive published data available to clearly describe the process; however, forty years of clinical studies on a standardized black cohosh extract show efficacy in the relief of hot flashes, profuse sweating, occasional sleeplessness, and support of mood.

Clinical Trials on Black Cohosh

A randomized, placebo-controlled, double-blind study compared women who took standardized black cohosh extract with women taking conjugated estrogen or a placebo. At the end of the study, the women taking the standardized black cohosh extract showed improvement relative to the placebo as measured by the Kupperman Menopausal Index, the Hamilton Anxiety Scale, and the maturation index of vaginal epithelium. No clear improvement of menopausal complaints was observed in the control group. This study demonstrated clinical and statistical improvement of symptoms by the women taking the standardized black cohosh extract.

AM Formula
Ginseng has an ancient reputation as a tonic. In folk medicine, ginseng has been ascribed “masculine” properties; however, ginseng has been used by both men and women for a variety of applications. The Complete German Commission E Monograph has approved ginseng to combat fatigue and weakness, as a restorative for declining stamina and impaired concentration, and as an aid to convalescence. A double-blind, placebo-controlled study with 384 symptomatic postmenopausal women showed a tendency towards slightly better overall symptom relief, and a significant improvement in mood and well-being after supplementation of ginseng extract for 16 weeks.

A recent study of postmenopausal women with menopausal syndromes reported that when Korean red ginseng was used for 30 days, Cornell Medical Index (CMI) and State-Trait Anxiety Inventory (STAI) score was decreased with significant improvement in fatigue, poor sleep quality, and depression. Therefore, Panax ginseng appears to be useful for relieving menopausal complaints.

Green Tea
Green tea is a dried product of the fresh shoot of the tea plant (Camellia sinensis) from which numerous biological activities have been reported. One component is caffeine. Caffeine has been extensively studied as an ergogenic (energy producing) aid. It has shown consistent ergogenic effects for the support of overall health, stamina, and the reduction of fatigue.

The green tea leaf extract in this product is standardized to contain 14% caffeine. Therefore, the green tea leaf extract delivers 35 mg of caffeine. One cup (7 ounces) of drip coffee provides 115-175 mg caffeine. The North American Menopause Society recommends moderation, not necessarily elimination, of caffeine intake (which could be 1-2 cups of coffee per day) for women experiencing hot flashes. The amount of caffeine in this product is less than 1/3 to 1/5 a cup of coffee.

Many researchers in the field of women's health suggest moderation in the intake of spicy foods, hot drinks, caffeine and alcohol as effective ways to alleviate hot flashes.Given the small amount of caffeine (35 mg) in this product, and the fact that green tea is in the AM formula, it seems reasonable that the positive ergogenic effects and healthy benefits of green tea supplementation outweigh the potential negative effects of caffeine.

Additionally, a 1998 study indicates that green tea supports women's breast health in a variety of ways. Green tea is a rich source of flavonoids and polyphenols, namely, catechins and flavonols. The catechins, also known as tea polyphenols, which occur in significant quantities in green tea, are catechin, epicatechin, gallocatechin, epigallocatechin, epicatechin gallate, and epigallocatechin gallate (EGCG). A study has indicated that EGCG supports healthy breast cell development.

PM formula:
The ingredients in the PM tablet of AM/PM Menopause Formula are included to promote relaxation and sleep. Poor sleep quality can lead to medical, psychological, and social disturbances. Conventional medical treatment for sleep problems includes psychological and pharmacological approaches.

However, use of frequently prescribed sleep or sedative medications can lead to dependency and cause unwanted side effects or problematic withdrawal symptoms. The following herbs, commonly used for their relaxing or sedative properties, do not demonstrate side effects such as tolerance, habituation, and addiction.

Valerian (Valeriana officinalis) has been reported to have sleep inducing and calming effects in in-vivo studies and clinical trials. A placebo-controlled, crossover trial of 128 volunteers reported 400 mg of valerian extract at bedtime led to improved sleep quality, decreased sleep latency, and reduced the number of night awakenings. Two other clinical studies using 400-900 mg valerian before bedtime also demonstrated improved sleep quality. In a double-blind, cross-over, placebo-controlled trial, subjective sleep latency and wake time after sleep-onset were reduced by more than half after a 900 mg dose, with a smaller effect after 450 mg. One electroencephalographical (EEG) study reported 135 mg of aqueous, dried extract of valerian, taken three times daily, improved delta sleep and decreased stage 1 sleep.

Recently, two human trials also demonstrated that valerian extract was effective in improvement of sleep structure and perception in subjects. In general, clinical studies with valerian extracts suggest that the mild sleep-inducing effect of valerian decreases sleeps latency and improves sleep quality.

L-theanine is one of the major components of amino acids in green tea. However, L-theanine does not contain any caffeine, even though it is from green tea.

L-theanine's effect on brain amino acids and neurotransmittors has been investigated. In clinical trials, L-theanine causes significant increases of certain neurotransmitter concentrations in brain, which promotes muscle relaxation and improves sleep.

The dried strobile of Hops (Humulus lupulus) is a popular sleep aid. Hops have been used for centuries for gastrointestinal health support, and have more recently been used to support healthy sleep.Key constituents of hops include a volatile oil, valerianic acid, phytoestrogenic substances, tannins, and flavonoids. Hops have been demonstrated to induce sleep.


AM: One (white) AM tablet in the morning.
PM: One (purple) PM tablet approximately 30-45 minutes before bedtime. It may take four to five weeks to achieve full benefits. Continue use to maintain benefits.


As a good health program, we encourage you to see your health care practitioner on a regular basis. If you are pregnant, nursing, or considering pregnancy, seek the advice of your health care practitioner before using this product.

How Is It Supplied?
77206;60 Tablets

Storage Recommendations

Store at controlled room temperature, 59 to 86F (15-30C)

Amount/Serving %DV
Total Carbohydrate <1mg <1%
Green Tea (Camellia sinensis) Leaf Extract 250mg
Panax Ginseng Root Extract standardized to contain 7% ginsenosides 100mg
Black Cohosh (Cimicifuga racemosa) Root and Rhizome Extract 20mg
Total Carbohydrate <1mg <1%
Valerian (Valeriana officinalis) Root Extract 200mg
Hops (Humulus lupulus) Flower Extract 6.6:1 100mg
L-Theanine (Suntheanine® brand) 50mg
Black Cohosh (Cimicifuga racemosa) Root and Rhizome Extract 20mg

This product does not contain
artificial flavoring
dairy products
ingredients of animal origin

All colors used are from natural sources.

Caution: Women who are pregnant or nursing should not use this product. If taking prescription drugs, consult your healthcare practitioner prior to use. Discontinue use and consult a healthcare practitioner if you have a liver disorder or develop symptoms of liver trouble, such as abdominal pain, dark urine, or jaundice.
Caution: PM Formula May impair your ability to drive or operate heavy equipment. Due to additive sedative effect, avoid using with alcohol.

Suntheanine, a patented form of L-Theanine, is a trademark of Taiyo International, Inc.
Manufactured by an FDA-registered Drug Establishment.
This product has a tamper-evident blister sheet. Do not use if foil or plastic is punctured!
ITI evidence-based natural medicines are the only choice of doctors who rely on the fact base of premier science to deliver patient results.

Based on 2000 calorie diet.Other Ingredients: AM Formula: cellulose, modified cellulose gum, stearic acid, modified cellulose, titanium dioxide color, magnesium stearate, silicon dioxide, soy lecithin, vegetable glycerin, and carnauba wax.

PM Formula: cellulose, modified cellulose, modified cellulose gum, magnesium stearate, silicon dioxide, carrot color, soy lecithin, carnauba wax, and paprika extract color.

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