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DMG-containing calcium pangamate was popular with Russian athletes and cosmonauts because it was reputed to enhance oxygenation at the cellular level, reduce fatigue and enhance physical stamina. None of those claims, however, was ever substantiated. DMG is neither a vitamin nor an essential nutrient. DMG is also known as N, N-dimethylglycine, (dimethylamino) acetic acid and N-methylsarcosine. DMG is a solid, water-soluble substance. DMG should not be confused with TMG (trimethylglycine or betaine). TMG is involved in the methylation of homocysteine to form methionine (see Trimethylglycine). DMG is absorbed from the small intestine and from there transported by the portal circulation to the liver. DMG is metabolized in the liver to monomethylglycine or sarcosine which, in turn, is converted to glycine. Dimethylglycine dehydrogenase, a flavoprotein, is the enzyme that catalyzes the oxidative demethylation of DMG to sarcosine. The methyl group produced in this reaction returns to the one carbon pool at the level of N10-hydroxymethyl-tetrahydrofolic acid. DMG itself is formed from trimethylglycine or betaine. DMG that is not metabolized in the liver is transported by the circulatory system to various tissues in the body.
Taking supplemental DMG can have a wide range of possible beneficial effects, including helping the body maintain high energy levels and boosting mental acuity. DMG has been found to enhance the immune system and to reduce elevated blood cholesterol and triglyceride levels. It improves oxygen utilization by the body, helps to normalize the functioning of many important organs. It may also be useful for controlling epileptic seizures. DMG (dimethylglycine) is basically the amino acid glycine attached to two methyl groups. DMG is a normal physiologically active nutrient found in low levels in such foods as cereal grains, liver and beans. Humans also naturally produce DMG in small amounts. As a nutritional supplement, DMG acts as a building block for the synthesis of many important substances such as choline, SAM-e, the amino acid methionine, several hormones, neurotransmitters and DNA.
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