Alpha Keto Glutarate has been shown to help patients with Hyperparathyroidism by reducing the elevated levels of the mineral phosphate and calcium in the blood. Phosphate and calcium levels are normally kept in balance by our bodies natural chemistry, but hyperparathyroidism disrupts this control mechanism. Importance of adding Calcium-alpha-ketoglutarate in supplements Bodybuilders consume is to help normalize the calcium levels in blood due to the high intake of proteins such as Micellar casein, Whey protein, and other Bodybuilding supplements that contain high amounts of calcium and phosphate. Hyperparathyroidism will cause muscle weakness, muscle loss, and other health issues that will keep a bodybuilder from developing adequate muscles to compete. Both proteins were reconstituted into phospholipid vesicles and their transport activities were measured. High, delta pH-dependent, 2-cyanocinnamate-sensitive pyruvate uptake was measured in vesicles containing only the 34-kDa protein. alpha-Ketobutyrate and other alpha-ketomonocarboxylic acids were competitive inhibitors of the pyruvate uptake, whereas di- and tricarboxylates had only small effects. alpha-Ketoglutarate-alpha- ketoglutarate exchange could only be measured in vesicles containing the 31.5-kDa protein. The molecular weight of this protein and its functional properties were similar to those of the alpha-ketoglutarate carrier isolated by a different method.
Arginine alpha-ketoglutarate (AKG) is a salt formed by combining two molecules of the amino acid Arginine and one molecule of alpha-ketoglutarate. Because AKG seems to be involved in amino acid synthesis and protein availability, many athletes supplement with AKG as a way to increase muscle mass and strength – although the evidence for its effectiveness is this regard is quite limited. It Increases muscle size and strength, Reduces body fat, Stimulates the immune system. Alpha Keto Glutarate has been used to treat patients suffering from burns, surgery, malnutrition and other trauma. Although the precise mechanism is unknown, AKG treatment decreases muscle protein catabolism (breakdown) and/or increases protein synthesis, in addition to promoting wound healing. AKG may promote the secretion of anabolic hormones such as insulin and growth hormone and increase amino acid metabolism (glutamine & arginine), which may help explain some of the clinical findings.'
Arginine and Arginine are precursors of nitric oxide and polyamines, respectively -metabolites which participate in a number of metabolic functions. AKG supplements have been shown to promote growth hormone and insulin secretion with anabolic effects in postoperative patients. Their intermediary metabolites (glutamine & proline) may also have beneficial effects in promoting recovery from trauma. In animal studies, AKG supplementation increases levels of arginine and glutamine in skeletal muscles and stimulates immune system function compared to animals not receiving AKG. The immunomodulatory properties found with AKG suggest that it may enhance host-defense mechanisms, particularly during injury and acute stress. Alpha Keto Glutarate supplements have been shown to improve growth rates in small children. The AKG supplements resulted in elevated concentrations of anabolic (growth) hormones and amino acid metabolites, including insulin-like growth factor 1 (IGF1), glutamine and glutamate. In another study of healthy men, AKG given at 10 grams per day resulted in a 20-30% elevation in insulin (another anabolic hormone), which were not observed with supplementation of either Arginine or alpha-ketoglutarate alone.